何隆薇,男,教授,博士生導師。2015獲湖南大學化學專業博士學位,随後入職濟南大學,曆任講師、副教授;2020年加入2003网站太阳集团,入選2003网站太阳集团高層次青年優秀人才。研究方向主要包括功能熒光分子設計及生物醫學應用,迄今以第一/通訊作者在Chem. Soc. Rev.、Chem. Sci.、ACS Appl. Mater. Interfaces、Anal. Chem.、ACS Sensor.、Chem. Comm.、Front. Bioeng. Biotechnol.、J. Mater. Chem. B、Chem.-Eur. J.等著名國際期刊上共發表30餘篇論文,其中一區論文20餘篇、高被引論文2篇。主持國家自然科學基金青年項目、湖南省自然科學基金、山東省自然科學基金、國家重點實驗室開放基金、2003网站太阳集团高層次人才項目等。
長期歡迎對本研究方向感興趣的同學報考本課題組的博士和碩士研究生!聯系方式:郵箱helongwei0110@163.com。
一、主持科研項目:
1.國家自然科學基金青年項目:編号21605059;新型單獨及連續識别亞硝酰氫(HNO)/一氧化氮(NO)比率單熒光探針的設計、合成及生物成像應用研究;2017/01-2019/12;20萬元。
2.湖南省自然科學基金面上項目:編号2022JJ30484;構建高對比度近紅外熒光探針用于精準腫瘤手術導航研究;2022.1-2024.12;5萬。
3.山東省自然科學博士基金項目:編号ZR2016BB26;基于多信号模式熒光探針區分檢測半胱氨酸/高半胱氨酸、谷胱甘肽和硫化氫及生物熒光成像研究;2016/11-2018/11;8萬元。
4.化學生物傳感與計量學國家重點實驗室開放基金:編号2021013;構建高對比度近紅外熒光探針及腫瘤手術導航研究;2022.4-2024.4;3萬。
5.2003网站太阳集团高層次人才啟動項目:編号201RGC012 /有機小分子熒光探針構建及腫瘤分子影像研究,2020/9-2025/9,300萬。
二、代表性論文:
1.Longwei He, Baoli Dong, Yong Liu and Weiying Lin*,Fluorescent chemosensors manipulated by dual/triple interplaying sensing mechanisms,Chemical Society Reviews, 2016, 45(23): 6449−6461.(Highly Cited Paper,中科院一區Top,IF =60.6)
2.Longwei He,Xueling Yang, Xiuqi Kong, Weiying Lin*,A multi-signal fluorescent probe for simultaneously distinguishing and sequentially sensing cysteine/homocysteine, glutathione, and hydrogen sulfide in living cells,Chemical Science, 2017, 8(9): 6257-6265.(Highly Cited Paper,中科院一區Top,IF = 9.9)
3.ongbin Zhong,Renfeng Jiang,Jiayu Zeng, Xiangyang Gong, Xuefeng Yang,Longwei He,*Lin Yuan, and Dan Cheng,*Enhancing the Selectivity of Leucine Aminopeptidase Near-Infrared Fluorescent Probes for Assisting in Surgical Tumor Resection,Analytical Chemistry,2023,95, 2428-2435.
4.Yiteng Ding,Rongbin Zhong,Renfeng Jiang, Xuefeng Yang,Longwei He,*Lin Yuan, and Dan Cheng,Redox-Reversible Near-Infrared Fluorescent Probe for Imaging of Acute Kidney Oxidative Injury and Remedy,ACS Sensors,2023,8, 914−922.(中科院一區Top,IF = 9.6)
5.Songjiao Li, Peipei Wang, Miantai Ye, Ke Yang, Dan Cheng, Zhiqiang Mao,Longwei He,*Zhihong Liu, A cysteine-activatable near-infrared fluorescent probe for dual-channel tracking lipid droplets and mitochondria in epilepsy,Analytical Chemistry,2023, Accepted.(中科院一區Top,IF = 8.0)
6.Songjiao Li, Ke Yang, Ying Liu, Peipei Wang, Dan Cheng,*Longwei He,*An endoplasmic reticulum-targeted near-infrared probe for monitoring HClO fluctuation in diabetic mice and human blood,Sensors and Actuators: B. Chemical,2023,379, 133253.(中科院一區Top,IF = 9.2)
7.Longwei He,Weiying Lin*, Qiuyan Xu, Mingguang Ren, Haipeng Wei, Jianyong Wang,A simple and effective “capping” approach to readily tune the fluorescence of near-infrared cyanines,Chemical Science, 2015, 6(8): 4530–4536.(中科院一區Top,IF = 9.9)
8.Longwei He, Yunzhen Yang, Weiying lin*,Rational design of a rigid fluorophore−molecular rotor-based probe for high signal-to-background ratio detection of sulfur dioxide in viscous system,Analytical Chemistry, 2019, 91(23), 15220−15228.(中科院一區Top,IF =8.0)
9.Longwei He, Xueling Yang, Kaixin Xu and Weiying Lin*,Improved aromatic substitution-rearrangement-based ratiometric fluorescent cysteine-specific probe and its application of real-time imaging under oxidative stress in living zebrafish,Analytical Chemistry, 2017, 89(17): 9567–9573. (中科院一區Top,IF = 8.0)
10.Longwei He, Xueling Yang, Kaixin Xu, Yunzhen Yang, Weiying lin*,A multifunctional logic gate by means of a triple-chromophore fluorescent biothiol probe with diverse fluorescence signal patterns,Chemical Communications, 2017, 53(98): 13168-13171.(中科院二區Top,IF = 6.0)Longwei He, Xueling Yang, Kaixin Xu, Weiying Lin*,A mitochondria-targeted fluorescent probe for imaging endogenous malondialdehyde in HeLa cells and onion tissues,Chemical Communications, 2017, 53(29): 4080-4083.(中科院二區Top,IF = 6.0)
11.Longwei He,Qiuyan Xu, Yong Liu, Haipeng Wei, Yonghe Tang, Weiying Lin*,Coumarin-based Turn-On fluorescence probe for specific detection of glutathione over cysteine and homocysteine,ACS Applied Materials & Interfaces, 2015, 7(23): 12809−12813.(中科院二區Top,IF =10.3)
12.Longwei He,Weiying Lin*, Qiuyan Xu, Haipeng Wei,A new strategy to construct FRET platform for ratiometric sensing hydrogen sulfide,Chemical Communications, 2015, 7(8): 12809−12813.(中科院二區Top,IF = 6.0)
13.Longwei He,Weiying Lin*,Qiuyan Xu, Haipeng Wei,A unique type of pyrrole-based cyanine fluorophores with turn-on and ratiometric fluorescence signals at different pH regions for sensing pH in enzymes and living cells,ACS Applied Materials & Interfaces,2014, 6(24): 22326−22333. (中科院二區Top,IF = 10.3)
14.Xiangyang Gong, Dan Cheng*, Wei Li*, Yang Shen, Rong Peng, Ling Shi,*Longwei He*, Lin Yuan, A highly selective ratiometric molecular probe for imaging peroxynitrite during drug-induced acute liver injury,Journal of Materials Chemistry B, 2021, 9, 8246–8252. (中科院二區Top,IF = 7.5)
15.Songjiao Li, Peipei Wang, Ke Yang, Ying Liu, Dan Cheng,Longwei He,*Construction of HClO activated near-infrared fluorescent probe for imaging hepatocellular carcinoma,Analytica Chimica Acta,2023, DOI: 10.1016/j.aca.2023.341009.
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