碩士研究生導師-唐國濤

唐國濤，男，博士，講師，碩士生導師。1974年12月生于湖北京山。1993-1997年 湖北中醫學院中藥系，獲醫學學士學位。1997-2001年 江蘇康緣藥業工作。

2001-2004年 湖北中醫學院中藥學專業，獲中藥學碩士學位。2006-2010年 複旦大學2003网站太阳集团藥劑學專業，獲藥劑學博士學位。2004年起在2003网站太阳集团任教。主持省市廳級課題6項，在國内外期刊發表論文40餘篇，授權專利3項。

主要研究方向：

1.藥物化學方向：針對腫瘤微環境中腫瘤血管增生，低氧，糖酵解，低pH值等特征， 以微管蛋白，低氧誘導因子及VEGF，糖酵解相關蛋白酶，pH調節相關蛋白為靶點，通過計算機模拟分子對接，設計合成多靶點腫瘤微環境響應小分子抗腫瘤化合物。

2.新藥研究與開發：化學藥物合成與制劑的研究開發、中藥及其制劑的研究開發（實驗室具備中試條件）。

主持或參加科研項目

1.湖南省自然科學基金面上項目，2020JJ4534，含芳基脲結構的三甲氧基黃酮衍生物的合成及抗腫瘤活性研究，2020-2022，5.0萬，進行中，主持

2.湖南省教育廳高校創新平台開放基金項目，17K082，肝癌共定位FA-GC-FUA納米前藥用于自殺基因遞送及其協同抗腫瘤作用研究，2017.9-2018.12，5.0萬，已結題，主持。

3.湖南省教育廳一般項目，13C833，PEG-b-C16酸敏釋藥聚合物膠束腫瘤靶向給藥系統的研究，2014.1-2015.12，1.0萬，已結題，主持

4.湖南省中醫藥管理局課題，201162，脂麻杆抗炎活性成分研究，2012-2013, 1.5萬，已結題，主持。

發表論文情況

1.Xueyan Sun; Yijiao Peng; Jingduo Zhao; Zhizhong Xie; Xiaoyong Lei; Guotao Tang（通訊作者). Discovery and development of tumor glycolysis rate-limiting enzyme inhibitors. Bioorganic Chemistry, 2021, 112(104891).  

2.Xiong, Runde; Peng, Yijiao; Li, Zhen; Peng, Junmei; Xie, Zhi-Zhong; Lei, Xiao-Yong; He, Dongxiu; Tang, Guotao（通訊作者). Design, synthesis, and biological evaluation of 3 ',4 ',5 '-trimethoxy evodiamine derivatives as potential antitumor agents. Drug Development Research, 2021, 82: 1021-1032.  

3.Deng, Xiangping; Pi, Yiyuan; Li, Zhongli; Xiong, Runde; Liu, Juan; Zhao, Jingduo; Xie, Zhizhong; Lei, Xiaoyong; Tang, Guotao（通訊作者). FB-15 inhibits MGC-803 cells growth by regulating energy metabolism. Chemico-Biological Interactions, 2020, 327: 0-109186.  

4.Liurenbo; Dengxiangping; Pengyijiao; Fengwanshi;Xiongrunde; Zouyang; Leixiaoyonh; Xiezhizhong; Zhengxin; tangguotao（通訊作者). Synthesis and biological evaluation of novel 5,6,7-trimethoxy flavonoid salicylate derivatives as potential anti-tumor agents. Bioorganic Chemistry, 2020, 96(103652): 1-15.

5.Xiangping Deng, Yijiao Peng, Jingduo Zhao, Xiaoyong Lei, Xing Zheng, Zhizhong Xie and Guotao Tang*（通訊作者), Anticancer Activity of Natural Flavonoids: Inhibition of HIF-1α Signaling Pathway, Current Organic Chemistry, 2019, 23, 2945-2959.

6.Runde Xiong, Dongxiu He, Xiangping Deng, Juan Liu, Xiaoyong Lei, Zhizhong Xie, Xuan Cao, Yanming Chen, Junmei Peng, Guotao Tang*（通訊作者), Design, synthesis and biological evaluation of tryptamine salicylic acid derivatives as potential antitumor agents. Med. Chem. Commun., 2019, 10, 573–583.

7.Xiangping Deng, Renbo Liu, Junjian Li, Zhongli Li, Juan Liu, Runde Xiong, Xiaoyong Lei, Xing Zheng,Zhizhong Xie, Guotao Tang*（通訊作者） Design, synthesis and preliminary biological evaluation of 3′,4′,5′-trimethoxy flavonoid salicylate derivatives as potential anti-tumor agents. New Journal of Chemistry, 2019, 43:1874-1884.

8.Shujuan Xiong, Zhe Wanga, Juan Liu, Xiangping Deng, Runde Xiong, Xuan Cao, Zhizhong Xie, Xiaoyong Lei, Yanming Chen, Guotao Tang*（通訊作者） A pH-sensitive prodrug strategy to co-deliver DOX and TOS in TPGS nanomicelles for tumor therapy. Colloids and Surfaces B: Biointerfaces, 2019,173 : 346-355.

9.Xiangping Deng, Zhongli Li, Runde Xiong, Juan Liu, Renbo Liu, Junmei Peng, Yanming Chen, Xiaoyong Lei, Xuan Cao, Xing Zheng, Zhizhong Xie*, Guotao Tang*（通訊作者） FS-7 inhibits MGC-803 cells growth in vitro and in vivo via down-regulating glycolysis. Biomedicine & Pharmacotherapy. 2019,109 : 1659–1669.

10.Zhe Wang, Xiangping Deng, Shujuan Xiong, Runde Xiong, Juan Liu, Liu Zou, Xiaoyong Lei, Xuan Cao, Zhizhong Xie, Yanming Chen, Yunmei Liu, Xing Zheng* and Guotao Tang*（通訊作者）. Design, synthesis and biological evaluation of chrysin benzimidazole derivatives as potential anticancer agents. Nat Prod Res, 2018, 32(24): 2900-2909

11.Liu Zou, Shujuan Xiong, Xiangping Deng, Juan Liu, Runde Xiong, Zhe Wang, Xuan Cao, Yanming Chen, Yu Guo*, Guotao Tang*（通訊作者）. Preparation of scutellarin loaded TPGS polymeric micelles and evaluation of its pharmacokinetics and pharmacodynamics effects in rats Acta Poloniae Pharmaceutica - Drug Research. 2018,75(6):1305-1312.

12.Zhe Wang, Xiangping Deng, Runde Xiong, Shujuan Xiong, Juan Liu, Xuan Cao, Xiaoyong Lei, Yanming Chen, Xing Zheng* Guotao Tang*（通訊作者）. Design, synthesis and biological evaluation of 3′,4′,5′-trimethoxy flavonoid benzimidazole derivatives as potential anti-tumor agents. MedChemComm, 2018, 9:305-315.

13.Zhe Wang, Xiangping Deng, Jinsong Ding, Wenhu Zhou, Xing Zheng* and Guotao Tang*（通訊作者）. Mechanisms of drug release in pH-sensitive micelles for tumour targeted drug delivery system: A review. Int J Pharm, 2018, 535:253-260.

14.Xiangping Deng, Zihao Zhao, Shujuan Xiong, Runde Xiong, Juan Liu, Zhe Wang, Liu Zou, Xiaoyong Lei, Xuan Cao, Zhizhong Xie, Yanming Chen, Xing Zheng, Yunmei Liu* and Guotao Tang*（通訊作者）. Synthesis and evaluation of antitumour activity in vitro and in vivo of chrysin salicylate derivatives. Nat Prod Res, 2018. 32（18）：2178-2186.

15.Xiangping Deng, Zhe Wang, Juan Liu, Shujuan Xiong, Runde Xiong, Xuan Cao, Yanming Chen, Xing Zheng* and Guotao Tang*（通訊作者）. Design, synthesis and biological evaluation of flavonoid salicylate derivatives as potential antitumor agents. RSC Adv, 2017, 7:38171-38178.

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