一、基本情況
何隆薇，男，教授，博士生導師；全球Top 2%頂尖科學家（2024，愛思唯爾與美國斯坦福大學聯合發布）。2015年獲湖南大學化學專業博士學位，随後入職濟南大學，曆任講師、副教授；2020年加入2003网站太阳集团，入選2003网站太阳集团高層次“青年優秀”人才，任特聘教授。兒科罕見病教育部重點實驗室、湖南省血栓性疾病防治臨床醫學研究中心、湖南省普通高等學校影像精準診療與輻射防護重點實驗室骨幹成員。主要從事診斷/治療型熒光分子探針、醫藥氣體分子供體設計及生物醫學應用的研究。主持國家自然科學基金、湖南省自然科學基金、山東省自然科學基金、國家重點實驗室開放課題、河南師範大學化學學科開放課題、2003网站太阳集团高層次人才項目等。迄今在Chem. Soc. Rev.、Chem. Sci.、Anal. Chem.、J. Hazard. Mater.、Adv. Healthc. Mater.、ACS Sensor.、ACS Appl. Mater. Interfaces、Sensor. Actuat.B. Chem.、Chem. Comm.、Analy. Chim. Acta、J. Mater. Chem. B等著名國際期刊上共發表50餘篇論文，共被引用5000餘次，H-Index 27，其中入選高被引論文4篇、一區論文30餘篇；授權專利5項。
長期歡迎對本研究方向感興趣的同學報考加入本課題組的博士後、博士研究生和碩士研究生！聯系方式：郵箱helongwei0110@163.com。
二、研究領域
1. 診斷/治療型熒光分子探針：主要進行疾病标志物的可視化檢測、疾病發生發展機制、藥物篩選，以及熒光成像指導的腫瘤手術導航/光動力療法/聲動力療法/氣體療法等的研究。
2. 醫藥氣體分子供體：主要進行心血管疾病、腦疾病、炎症、癌症等疾病的高效治療研究。
三、工作及學習經曆
2020/9-至今，2003网站太阳集团，2003网站太阳集团，特聘教授
2015/7-2020/9，濟南大學，熒光探針與生物醫學成像研究院，講師、副教授
2010/9-2015/6，湖南大學，化學化工學院，博士
2006/9-2010/6，黃山學院，化學化工學院，本科
四、社會兼職
Med. Gas Res.、Front. Bioeng. Biotechnol.、Chemosensors等期刊的編委/客座主編。
五、教學工作
指導本科生大學生創新訓練計劃項目、畢業設計；承擔《藥學科研設計》研究生課程。
六、承擔課題
1. 國家自然科學基金青年項目：編号21605059；新型單獨及連續識别亞硝酰氫（HNO）/一氧化氮（NO）比率單熒光探針的設計、合成及生物成像應用研究；2017/01-2019/12。
2. 湖南省自然科學基金面上項目：編号2022JJ30484；構建高對比度近紅外熒光探針用于精準腫瘤手術導航研究；2022/1-2024/12。
3. 山東省自然科學博士基金項目：編号ZR2016BB26；基于多信号模式熒光探針區分檢測半胱氨酸/高半胱氨酸、谷胱甘肽和硫化氫及生物熒光成像研究；2016/11-2018/11。
4. 化學生物傳感與計量學國家重點實驗室（湖南大學）開放基金：編号2021013；構建高對比度近紅外熒光探針及腫瘤手術導航研究；2022/4-2024/4。
5. 河南師範大學化學學科開放基金資助項目：編号: 2024Y13；脂滴相關細胞器互作熒光傳感研究；2024/06-2025/12。
6. 2003网站太阳集团高層次人才啟動項目：編号201RGC012;有機小分子熒光探針構建及腫瘤分子影像研究，2020/9-2025/9。
七、代表性文章
1)Minhui Liu, Jiayu Zeng, Wanting Zhang, Jia Lei, Songjiao Li, Jia Zhou*, Dan Cheng*,Longwei He*, Fabrication of a Near-Infrared-Emissive Probe for Detecting Dipeptidyl Peptidase 4 in the Liver of Diabetic Mice and Clinical Serum,Analytical Chemistry,2024,96(29), 11890.
2)Jiayu Zeng, Minhui Liu, Ting Yang, Jia Huang, Songjiao Li, Wanting Zhang, Dan Cheng*,Longwei He*, Jia Zhou*, Two-dimensional design strategy to construct smart dual-responsive fluorescent probe for the precise tracking of ischemic stroke,Chinese Chemical Letters,2024, 110166.
3)Yuqing Xia, Qian Liu, Hongshuai Zhang, Xuefeng Yang,Longwei He*, Dan Cheng*, A tumor microenvironment-activated near-infrared photosensitizer enable efficient photodynamic therapy of breast tumor,Sensors and Actuators B: Chemical,2024,419, 136382.
4)Renfeng Jiang, Yuqing Xia, Qian Liu, Hongshuai Zhang*, Xuefeng Yang,Longwei He* and Dan Cheng*, Carboxylesterase-activated near-infrared fluorescence probe for highly sensitive imaging of liver tumors,Journal of Materials Chemistry B,2024,12, 1530-1537.
5) Rongbin Zhong, Renfeng Jiang, Jiayu Zeng, Xiangyang Gong, Xuefeng Yang,Longwei He,* Lin Yuan, and Dan Cheng,* Enhancing the Selectivity of Leucine Aminopeptidase Near-Infrared Fluorescent Probes for Assisting in Surgical Tumor Resection,Analytical Chemistry, 2023,95, 2428-2435.
6) Yiteng Ding, Rongbin Zhong, Renfeng Jiang, Xuefeng Yang,Longwei He,* Lin Yuan, and Dan Cheng,* Redox-Reversible Near-Infrared Fluorescent Probe for Imaging of Acute Kidney Oxidative Injury and Remedy,ACS Sensors,2023,8, 914−922.
7) Songjiao Li, Peipei Wang, Miantai Ye, Ke Yang, Dan Cheng, Zhiqiang Mao,* Longwei He,* Zhihong Liu,Cysteine-activatable near-infrared fluorescent probe for dual-channel tracking lipid droplets and mitochondria in epilepsy,Analytical Chemistry, 2023,95(11), 5133–5141.
8) Dan Wang, Li-Jie Zhang, Ming-Hui Liu, Fang-Fang Du, Ze-Ya Shen,Longwei He,* Li-Li Wang,* Aggregation enhanced FRET: A simple but efficient strategy for the ratiometric detection of uranyl ion,Journal of Hazardous Materials,2023,454, 131497.
9)Jiayu Zeng, Ting Yang, Minhui Liu, Songjiao Li, Dan Cheng,* Longwei He,* Lysosome-targeted fluorescence probe for discriminating cysteine from homocysteine/glutathione and assessing autophagy in drug-induced liver injury, Sensors and Actuators: B. Chemical,2023,396, 134616.
10)Renfeng Jiang, Hongshuai Zhang, Qian Liu, Xuefeng Yang,Longwei He,* Lin Yuan, and Dan Cheng*, De Novo Design of Near-Infrared Fluorescent Agents Activated by Peroxynitrite and Glutathione-Responsive Imaging for Diabetic Liver Disease, Advanced Healthcare Materials,2023, 2302466.
11)Yin Liu, Xinru Liu, Qian Liu, Donghong Li, Dan Cheng,* Longwei He,* Engineering a Highly Selective Leucine Aminopeptidase Near-Infrared Fluorescence Probe for Early Diagnosis of Diabetic Nephropathy, Sensors and Actuators: B. Chemical,2023,402, 135127.
12)Longwei He, Baoli Dong, Yong Liu and Weiying Lin*, Fluorescent chemosensors manipulated by dual/triple interplaying sensing mechanisms,Chemical Society Reviews,2016,45(23): 6449.
13) Longwei He, Xueling Yang, Xiuqi Kong,Weiying Lin*, A multi-signal fluorescent probe for simultaneously distinguishing and sequentially sensing cysteine/homocysteine, glutathione, and hydrogen sulfide in living cells, Chemical Science, 2017,8(9):6267.
14)Longwei He,Yunzhen Yang, Weiying lin*, Rational design of a rigid fluorophore−molecular rotor-based probe for high signal-to-background ratio detection of sulfur dioxide in viscous system,Analytical Chemistry,2019,91(23), 15220.
15)Longwei He, Qiuyan Xu, Yong Liu, Haipeng Wei, Yonghe Tang, Weiying Lin*, Coumarin-based Turn-On fluorescence probe for specific detection of glutathione over cysteine and homocysteine,ACS Applied Materials & Interfaces, 2015,7(23): 12809.