一、基本情況
楊瑞閣，化學生物學博士，特聘教授，博士生導師。主要從事中藥活性物質的發現、結構優化、生物活性及作用機制研究；藥用植物資源的可持續利用與保護研究。先後承擔中國自然科學基金青年科學基金、中國博士後面上、河南省重點研發與推廣專項（科技攻關）等課題。在J. Med. Chem.、Eur. J. Med. Chem.、Chin. Chem. Lett.、J. Agri. Food Chem.等SCI期刊發表論文30餘篇，其中ESI高被引論文4篇。
Email:yrggg@163.com
二、研究領域
1. 天然抗菌藥物先導發現及機制研究。
2.藥用植物資源保護研究。
三、社會兼職
Traditional Medicine Research期刊雜志青年編委。
四、教學工作
目前承擔課程：研究生天然藥物化學研究進展。
五、承擔課題
1.國家自然科學基金青年科學基金，項目号：32001926，2021.01-2023.12
2.中國博士後面上項目，項目号：2019M652585，2019.01-2020.12
3.河南省重點研發與推廣專項（科技攻關），項目号：232102111025，2023.01-2024.06
4.河南省重點研發與推廣專項（科技攻關），項目号：192102110054，2019.01-2020.12
六、代表性文章
1) Ruige Yang,1 LipingCui,1 Shengnan Xu, Yan Zhong, Ting Xu, Jifeng Liu, Zhenwei Lan, Shangshang Qin, Yong Guo* Membrane-Targeting Amphiphilic Honokiol Derivatives Containing an Oxazole Moiety as Potential Antibacterials against Methicillin-Resistant Staphylococcus aureus. J. Med. Chem. 2024, https://doi.org/10.1021/acs.jmedchem.4c01860.
2) Ting Xu,1 Xiaoting Yan,1 Ayue Kang, Longhua Yang, Xinhui Li, Yue Tian,Ruige Yang,* Shangshang Qin,* Yong Guo* Development of membrane-targeting fluorescent 2-phenyl-1H- phenanthro[9,10-d]imidazole-antimicrobial peptide mimic conjugates against methicillin- resistantStaphylococcus aureus.J. Med. Chem. 2024, 67(11), 9302−9317.
3) Hong Yao,1 Liping Cui,1 Hang Liu, Xueyu Li, Lin Shen,Ruige Yang,*, Shangshang Qin,*, Yong Guo* Quinoline-based anti-MRSA agents: Current development, structure-activity relationships, and mechanisms. Chin. Chem. Lett. 2024, 108511.
4) Wanqing Cheng,1 Ting Xu,1 Liping Cui, Zihan Xue, Jifeng Liu,Ruige Yang,* Shangshang Qin,* Yong Guo* Discovery of Amphiphilic Xanthohumol Derivatives as Membrane- Targeting Antimicrobials against Methicillin-Resistant Staphylococcus aureus.J. Med. Chem. 2023, 66(1), 962-975.
5) Ruige Yang,1 Enhua Hou,1 Wanqing Cheng, Xiaoting Yan, Tingting Zhang, Shihong Li, Hong Yao,* Jifeng Liu,* Yong Guo* Membrane-targeting neolignan-antimicrobial peptide mimic conjugates to combat methicillin-resistantStaphylococcus aureus (MRSA) infections.J. Med. Chem. 2022, 65(24), 16879-16892.
6) Ruige Yang,*,1, Zihan Xue1, Xinhui Li, Ting Xu, Yan Zhong, Songlin Hu, Shangshang Qin, Yong Guo* Novel natural osthole-inspired amphiphiles as membrane targeting antibacterials against methicillin-resistant Staphylococcus aureus (MRSA).Eur. J. Med. Chem. 2024, 271, 116449.
7) Zhiyan Liu,1 Meiyue Han,1 Xiaoting Yan, Wanqing Cheng, Zhenshuai Tang, Liping Cui,Ruige Yang,* Yong Guo* Design, synthesis, and biological evaluation of novel osthole-based isoxazoline derivatives as insecticide candidates. J. Agric. Food Chem. 2022, 70, 7921−7928.
8) Yong Guo, Meiyue Han, Yan Zhong, Xueyu Li, Songlin Hu, Ruige Yang* Discovery of Novel (+)-Nootkatone-Based Amine Derivatives as Potential Insecticide Candidates.J. Agric. Food Chem. 2024, 72, 17240−17247.