一、基本情況
唐國濤，藥劑學博士；講師，碩士生導師。主要腫瘤微環境響應小分子藥物的設計合成與開發，腫瘤微環境響應藥物給藥系統的研究與開發。先後承擔國家湖南省自然科學基金、湖南省教育廳重點項目、企業合作（委托）等課題。在Eur. J. Med. Chem.，Bioor. Chem等雜志發表研究論文20餘篇，授權專利3項。
Email: tgtzq@163.com
二、研究領域
1. 腫瘤微環境響應小分子藥物的設計合成與開發。
2. 腫瘤微環境響應藥物給藥系統的研究與開發。
三、工作及學習經曆
2004.7-至今 2003网站太阳集团，2003网站太阳集团，講師
2006.9-2010.1 複旦大學，2003网站太阳集团，博士
2001.9-2004.7 湖北中醫藥大學，中藥系，碩士
1997.07-2001.04，江蘇康緣藥業
1993.9-1997.7 湖北中醫學院，中藥系，藥士
四、社會兼職
無
五、教學工作
目前承擔課程：中醫藥學概論、制藥工藝與工程。
六、承擔課題
1.新型抗體藥物及其智能運輸系統湖南省重點實驗室開放課題，2022-KL02,苯甲酸修飾的苯并咪唑類LDHA抑制劑的設計合成與抗腫瘤活性研究.2022.10-2024.09,10萬，在研，主持。
2.湖南省教育廳, 重點項目, 22A0304, 含芳基脲結構的YC-1衍生物的設計、合成及抗腫瘤活性評價, 2023.01-2025.12, 8萬元, 在研, 主持
3.湖南省自然科學基金面上項目，2020JJ4534，含芳基脲結構的三甲氧基黃酮衍生物的合成及抗腫瘤活性研究，2020-2022，5.0萬，已結題，主持
七、代表性文章
1.Senyi Liao; Guang Wu; Zhizhong Xie; Xiaoyong Lei; Xiaoyan Yang; Sheng Huang; Xiangping Deng; Zhe Wang; Guotao Tang. pH regulators and their inhibitors in tumor microenvironment. European Journal of Medicinal Chemistry, 2024, 267: 116170
2.Jing Zhang; Jia Yu; Meijing Liu; Zhizhong Xie; Xiaoyong Lei; Xiaoyan Yang; Sheng Huang; Xiangping Deng; Zhe Wang; Guotao Tang. Small-molecule modulators of tumor immune microenvironment. Bioorganic Chemistry, 2024, 145: 107251.
3.Yiyang Li; Zhizhong Xie; Xiaoyong Lei; Xiaoyan Yang; Sheng Huang; Weixi Yuan; Xiangping Deng; Zhe Wang; Guotao Tang. Recent advances in pyruvate dehydrogenase kinase inhibitors: Structures, inhibitory mechanisms and biological activities. Bioorganic Chemistry, 2024, 144: 107160.
4.Chenglin Ouyang; Jing Zhang; Xiaoyong Lei; Zhizhong Xie; Xingyun Liu; Yong Li; Sheng Huang; Zhe Wang*; Guotao Tang*. Advances in antitumor research of HIF-1α inhibitor YC-1 and its derivatives. Bioorganic Chemistry, 2023, 133: 106400
5.Yang Zou; Na Lu; Xiaoyan Yang; Zhizhong Xie; Xiaoyong Lei; Xingyun Liu; Yong Li; Sheng Huang; Guotao Tang; Zhe Wang. Synthesis and anti-hepatocellular carcinoma evaluation of salicylic acid-modified indole trimethoxy flavonoid derivatives. RSC Med. Chem., 2023, 14, 1172–1185.
6.Xueyan Sun; Zhizhong Xie; Xiaoyong Lei; Sheng Huang; Guotao Tang; Zhe Wang. Research and development of N,N′-diarylureas as anti-tumor agents. RSC Med. Chem., 2023, 14, 1209–1226.
7.Xueyan Sun; Yin Zhao; Jingduo Zhao; Zhizhong Xie; Xiaoyong Lei; Xingyun Liu; Yong Li; Sheng Huang; Zhe Wang*; Guotao Tang*. Design, synthesis, and antitumor evaluation of trimethoxyflavonoid with arylurea structure against hepatocellular carcinoma. Drug Development Research, 2023, 84:406–422.
8.Xiangping Deng; Yang Zou; Renbo Liu; Yijiao Peng; Chenglin Ouyang; Junmei Peng; Xiaoyong Lei; Zhizhong Xie; Chong Li*; Guotao Tang*. Discovery of a Potential Multi-Target Anti-Tumor Agent via Structural Modification on Flavonoid. Polycyclic Aromatic Compounds, 2023, 43(2): 980-999.