一、基本情況
許婷，中藥學博士；師資博士後。主要從事天然産物的結構優化及其體内外抗菌活性及機制相關研究。在J. Med. Chem.（2篇，其中封面論文1篇，高被引一篇）， Eur. J. Med. Chem.， Ind. Crop. Prod.，Bioorg. Chem.，Biomed Pharmacother. 等國際主流學術期刊發表12篇SCI論文，其中中科院1區TOP 6篇。
Email: 18337173539@163.com
二、研究領域
1.天然藥物化學：天然産物的結構優化及其體内外抗菌活性及機制相關研究
三、工作及學習經曆
2023/10-至今，南華大學，2003网站太阳集团，師資博士後
2019/8-2023/8, 澳門科技大學，中藥質量研究國家重點實驗室，中藥學博士
2016/9-2019/7, 鄭州大學，2003网站太阳集团，生藥學碩士
四、承擔課題
1. 2003网站太阳集团博士後啟動金，基于天然産物黃腐醇類化合物的結構優化、抗MRSA活性及機制研究（5524BH002），2024.01-2025.12
七、代表性文章
1）Xu, T., Yan, X., Kang, A., Yang, R., Li, X., Tian, Y., Yang, R.*, Qin, S.*, Guo, Y.* Development of Membrane-Targeting Fluorescent 2-Phenyl-1H-phenanthro[9,10-d]imidazole-Antimicrobial Peptide Mimic Conjugates against Methicillin-Resistant Staphylococcus aureus (MRSA). Journal of Medicinal Chemistry, 2024, 67, 9302.
2) Cheng, W.#, Xu, T.#, Cui, L., et al. Development of Membrane-Targeting Fluorescent 2 Phenyl 1H phenanthro[9,10 d]imidazole-Antimicrobial Peptide Mimic Conjugates against Methicillin-Resistant Staphylococcus aureus. J. Med. Chem., 2023, 66, 962−975
3）Xu, T., Tian, W., Guo Y.*, Bai, L. P*., et al. Novel 1, 3, 4-thiadiazole/oxadiazole-linked honokiol derivatives suppress cancer via inducing PI3K/Akt/mTOR-dependent autophagy. Bioorganic Chemistry, 2021, 115, 105257.
4）Xu T., Zheng Z., Guo Y.*, Bai L.-P.*. Semisynthesis of novel magnolol-based Mannich base derivatives that suppress cancer cells via inducing autophagy. European Journal of Medicinal Chemistry, 2020, 205, 112663.
5）Xu, T., Meng, J. R., Cheng, W., Liu, J. Z., Chu, J., Zhang, Q., Ma N., Bai L.-P. *, Guo, Y. *. Discovery of honokiol thioethers containing 1, 3, 4-oxadiazole moieties as potential α-glucosidase and SARS-CoV-2 entry inhibitors. Bioorganic & Medicinal Chemistry. 2022, 67, 116838.
6）Zheng Z. #, Xu T.#, Liu Z., Tian W., Jiang ZH., Zhu GY., Li T., Gao J., Bai L.-P.*. Cryptolepine suppresses breast adenocarcinoma via inhibition of HIF-1 mediated glycolysis. Biomed Pharmacother. 2022, 153, 113319.
7）Xu, T., Wang, X.#, Zhang, Q., … Guo, Y.* Iodine-mediated oxidative cyclization for one pot synthesis of new 8-hydroxyquinaldine derivatives containing a N-phenylpyrazole moiety as pesticidal agents. Bioorganic & Medicinal Chemistry Letters, 2018, 28(20), 3376-3380.
8) Zhang, F., Guo, Y.*, Xu, T.*, et al. A membrane-targeting magnololderivative for the treatment ofmethicillin-resistantStaphylococcus aureus infections. Front. Microbiol., 2024, 15:1385585.