一、基本情況
郭勇，化學生物學博士；特聘教授，博士生導師。主要從事天然活性成分的發現、結構優化、生物活性及構效關系的研究。先後承擔國家自然基金—面上、青年基金項目、河南省優秀青年科學基金和湖南省自然科學基金部門聯合基金等課題。在J. Med. Chem., Chin. Chem. Lett., Eur. J. Med. Chem., J. Agri. Food Chem., Ind. Crop Prod., Bioorg. Chem.等SCI期刊發表論文50多篇，其中封面論文3篇，ESI高被引3篇。
Email: guoyong_122@163.com
二、研究領域
1. 天然藥物先導發現及機制研究。
2.含氮雜環活性功能小分子合成及生物活性評價。
三、社會兼職
Tradit Med Res、Current Topics in Medicinal Chemistry、molecules、Acta Materia Medica等雜志青年或客座編委
四、教學工作
目前承擔課程：本科生天然藥物化學、研究生高等藥物化學與藥學前沿進展等課程。
五、承擔課題
1. 國家自然科學基金面上項目，項目号：32272575，2023.1-2026.12
2. 湖南省自然科學基金部門聯合基金，項目号：2024JJ8141，2024.1-2026.12
六、代表性文章
1. Yang, R., Cui, Li, Xu, S., Zhong, Y., Xu, T., Liu, J., Lan, Z., Qin, S., Guo, Y*. Membrane-Targeting Amphiphilic Honokiol Derivatives Containing an Oxazole Moiety as Potential Antibacterials against Methicillin-Resistant Staphylococcus aureus, Journal of Medicinal Chemistry, 2024, https://doi.org/10.1021/acs.jmedchem.4c01860.
2. Xu, T., Yan, X., Kang, A., Yang, L., Li, X., Tian, Y., Yang, R. *, Qin, S. *, Guo, Y*. Development of membrane-targeting fluorescent 2-phenyl-1H-phenanthro [9, 10-d] imidazole-antimicrobial peptide mimic conjugates against methicillin-resistant Staphylococcus aureus. Journal of Medicinal Chemistry, 2024, 67(11), 9302-9317.
3. Yao, H., Cui, L., Liu, H., Li, X., Shen, L., Yang, R.*, Qin, S*., Guo, Y*. Quinoline-based anti-MRSA agents: Current development, structure-activity relationships, and mechanisms. Chinese Chemical Letters, 2024, 108511.
4. Yang, R., Cheng, W., Huang, M., Xu, T., Zhang, M., Liu, J., Qin, S., Guo, Y*. Novel membrane-targeting isoxanthohumol-amine conjugates for combating methicillin-resistant Staphylococcus aureus (MRSA) infections. European Journal of Medicinal Chemistry, 2024, 116274.
5. Cheng, W., Xu, T., Cui, L., Xue, Z., Liu, J., Yang, R.*, Qin, S*., Guo, Y*. Discovery of Amphiphilic Xanthohumol Derivatives as Membrane-Targeting Antimicrobials against Methicillin-Resistant Staphylococcus aureus. Journal of Medicinal Chemistry, 2023, 66(1), 962-975.
6. Yang, R., Hou, E., Cheng, W., Yan, X., Zhang, T., Li, S., Yao, H.*, Liu, J.*, Guo, Y*. Membrane-targeting neolignan-antimicrobial peptide mimic conjugates to combat methicillin-resistant Staphylococcus aureus (MRSA) infections. Journal of Medicinal Chemistry, 2022, 65(24), 16879-16892.
7. Guo, Y*., Hou, E., Wen, T., Yan, X., Han, M., Bai, L. P., Liu, J.*, Qin, S*. Development of membrane-active honokiol/magnolol amphiphiles as potent antibacterial agents against methicillin-resistant Staphylococcus aureus (MRSA). Journal of Medicinal Chemistry, 2021, 64(17), 12903-12916.