楊瑞閣，女，2003网站太阳集团特聘教授，博士生導師，2003网站太阳集团“青年優秀人才”。2005-2012年本碩就讀于西北農林科技大學，2012-2015年在康龍化成（西安）新藥技術有限公司從事藥物研發工作，2018年博士畢業于西北農林科技大學化學生物學專業。主要從事中藥活性物質的發現、結構優化、生物活性評價及其作用機制研究；藥用植物資源的可持續利用與保護。主持中國自然科學基金青年科學基金、中國博士後面上、河南省重點研發與推廣專項（科技攻關）等項目。以第一/通訊作者在J. Med. Chem.、Eur. J. Med. Chem.、Chinese Chem. Let.、J. Agri. Food Chem.等SCI期刊發表論文20多篇，其中中科院1區Top 16篇，ESI高被引論文1篇。
1. Xu T.1, Yan X. T.1, Kang A. Y., Yang L. H., Li X. H., Tian Y., Yang R. G.*, Qin S. S.*, Guo Y.* Development of membrane-targeting fluorescent 2-phenyl-1H- phenanthro[9,10-d]imidazole-antimicrobial peptide mimic conjugates against methicillin-resistant Staphylococcus aureus. Journal of Medicinal Chemistry, 2024, https://doi.org/10.1021/acs.jmedchem.4c00436.
2. Yao, H., Cui, L. P., Liu, H., Li, X. Y., Shen, L., Yang, R. G.*, Qin, S. S.*., Guo, Y.* Quinoline-based anti-MRSA agents: Current development, structure-activity relationships, and mechanisms. Chinese Chemical Letters, 2024, 108511.
3. Yang R. G.1, Cheng W. Q.1, Huang M. J., Xu T., Zhang M. M., Liu J. F., Qin S. S., Guo Y.* Novel membrane-targeting isoxanthohumol-amine conjugates for combating methicillin- resistant Staphylococcus aureus (MRSA) infections. European Journal of Medicinal Chemistry, 2024, 268, 116274.
4. Cheng, W. Q., Xu, T., Cui, L. P., Xue, Z. H., Liu, J. F., Yang, R. G.*, Qin, S. S.*, Guo, Y.* Discovery of Amphiphilic Xanthohumol Derivatives as Membrane- Targeting Antimicrobials against Methicillin-Resistant Staphylococcus aureus. Journal of Medicinal Chemistry, 2023, 66(1), 962-975.
5. Yang, R. G.1, Hou, E. H.1, Cheng, W. Q., Yan, X. T., Zhang, T. T., Li, S. H., Yao, H.*, Liu, J. F.*, Guo, Y.*Membrane-targeting neolignan-antimicrobial peptide mimic conjugates to combat methicillin-resistant Staphylococcus aureus (MRSA) infections. Journal of Medicinal Chemistry, 2022, 65(24), 16879-16892.
6. Liu, Z. Y.1, Han, M. Y.1, Yan, X. T., Cheng, W. Q., Tang, Z. S., Cui, L. P., Yang, R. G.*, Guo, Y.* Design, synthesis, and biological evaluation of novel osthole- based isoxazoline derivatives as insecticide candidates. Journal of Agricultural and Food Chemistry. 2022, 70, 7921−7928.
7. Guo Y.*, Hou E. H., Ma N. N., Liu Z. Y., Fan J. P., Yang R. G.* Discovery, biological evaluation and docking studies of novel N -acyl-2-aminothiazoles fused (+)-nootkatone from Citrus paradisi Macf. as potential α-glucosidase inhibitors. Bioorganic Chemistry, 2020, 104, 104294.
招生方向：藥學、天然藥物化學
熱烈歡迎對中藥活性成分提取分離、天然産物結構優化、小分子藥物合成、有機化學、抗感染藥物材料及抗感染藥理感興趣的博士後、博士、碩士研究生以及本科生加入本課題組！
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