一、基本情況
何穗穗,化學博士;講師,碩士生導師。主要從事生物醫藥傳感器開發及腫瘤診療一體化應用研究。先後承擔湖南省自然科學基金青年項目、湖南省衛健委項目、湖南省教育廳項目、衡陽市科技廳項目等。在Chemical Science、Analytical Chemistry、Chemical Engineering Journal、Analytica Chimica Acta等高水平雜志發表研究論文10餘篇,授權專利4項。
Email:hess@usc.edu.cn,QQ:1301582553
二、研究領域
1. 生物醫藥傳感器開發:新型多功能納米傳感器的設計合成及其用于疾病标志物、藥物分子等的便攜式即時檢測研究。
2.腫瘤診療一體化應用:基于腫瘤微環境的納米催化藥物體系的構建及多模式靶向腫瘤診療研究。
三、工作及學習經曆
2020/9-至今,2003网站太阳集团,2003网站太阳集团,講師
2015/9-2020/8,蘭州大學,化學化工學院,博士
2011/9-2015/6,曲阜師範大學,化學與化工學院,本科
四、社會兼職
無
五、教學工作
目前承擔課程:藥物分析、分析化學、藥學科研檢索、生物藥劑學與藥物動力學、了解生活中的納米科技等。指導本科生大學生創新訓練計劃項目、畢業論文等。
六、承擔課題
1.湖南省自然科學基金青年項目,級聯信号放大的溫敏型自組裝納米複合探針用于肝癌便攜式檢測研究(2023JJ40529),2023.1-2025.12,5萬;
2.湖南省衛生健康委員會項目,構建酸性解鎖生物礦化配位聚合物載體用于腫瘤的原位雙重催化治療(202213024185),2022.1-2024.12,2萬;
3.湖南省教育廳項目,CPs基納米載體用于近紅外光觸發原位合成藥物的協同抗癌性能研究(22C0204),2022.1-2024.12,1萬;
4.2003网站太阳集团博士科研啟動基金,構建智能礦化配位聚合物納米載體用于靶向線粒體的體内藥物合成和化療-光動力學聯合腫瘤治療(200XQD081),2021.01-2023.12,30萬;
5.衡陽市科技局項目,谷胱甘肽響應型納米探針的構建及其對癌症的便攜式診斷和原位激活的化學動力治療研究,2022.01-2024.12。
七、代表性文章
1)Li, Kailing1; Wang, Jun1; Wang, Jieqiong; Zheng, Zhi; Liu, Xinping; Wang, Jikai; Zhang, Chenjing;He, Suisui*; Wei, Hua*; Yu, Cui-Yun*;A Programmable Microfluidic Paper-Based Analytical Device for Simultaneous Colorimetric and Photothermal Visual Sensing of Multiple Enzyme Activities,Analytical Chemistry 2024,96(29):12181-12188.
2) Tian, Min1; Wang, Jun1; Xiang, Wang; Zheng, Zhi; Luo, Zhonghui; Jing, Shihan; Zheng, Yuxi; He, Suisui*; Wei, Hua*; Yu, Cui-Yun*; A dual-mode portable platform with spatiotemporal temperature–pressure signal readouts for ultrasensitive quantitative determination of cancer cells,Chemical Engineering Journal,2024,486: 150186.
3) Zhang, Jiaheng1; Wang, Jun1; Ouyang, Feijun; Zheng, Zhi; Huang, Xiaowan; Zhang, Haitao; He, Dongxiu;He, Suisui*; Wei, Hua*; Yu, Cui-Yun*; A smartphone-integrated portable platform based on polychromatic ratiometric fluorescent paper sensors for visual quantitative determination of norfloxacin,Analytica Chimica Acta,2023,1279: 341837.
4) He, Suisui; Lu, Siyu; Liu, Sha; Li, Tianrong; Li, Jieling; Sun, Shihao; Liu, Meilin; Liang, Kun; Fu, Xu; Chen, Fengjuan; Meng, Genping; Zhang, Lang; Hai, Jun*; Wang, Baodui*, Spatiotemporally controlled O2 and singlet oxygen self-sufficient nano photosensitizers enable the in vivo high-yield synthesis of drugs and efficient hypoxic tumor therapy, Chemical Science,2020,11(33): 8817-8827.
5)He, Suisui; Hai, Jun; Sun, Shihao; Lu, Siyu; Wang, Baodui*,Palladium Coordination Polymers Nanosheets: New Strategy for Sensitive Photothermal Detection of H2S, Analytical Chemistry,2019,91(16): 10823-10829.
6) Lu, Yu1; Wang, Song-Meng1;He, Suisui1; Huang, Qicheng1; Zhao, Cheng-Da; Yu, Shan; Jiang, Wei; Yao, Huan*; Wang, Li-Li*; and Yang, Liu-Pan*, An endo-functionalized molecular cage for selective potentiometric determination of creatinine,Chemical Science, 2024, https://doi.org/10.1039/D4SC04950K.
7)Li,Kailing1; Wang, Jun1;Liu,Li;Cao,Hui;Yang, Xu;Liu,Ying;Wang, Jikai;He, Suisui*; Wei, Hua*; Yu, Cui-Yun*; Pd(II)-based coordination polymer nanosheets for ratiometric colorimetric and photothermal dual-mode assay of serum alkaline phosphatase,Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 2023, 299, 122802.
8)He, Suisui1; Chai, Jian1; Lu, Siyu; Mu, Xijiao; Liu, Ruitong; Wang, Qiang; Chen, Fengjuan; Li, Yuee*; Wang, Jingang; Wang, Baodui*, Solution-phase vertical growth of aligned NiCo2O4 nanosheet arrays on Au nanosheets with weakened oxygen-hydrogen bonds for photocatalytic oxygen evolution,Nanoscale,2020,12(10): 6195-6203.
9)He, Suisui; Hai, Jun; Li, Tianrong; Liu, Sha; Chen, Fengjuan*; Wang, Baodui*, Photochemical strategies for the green synthesis of ultrathin Au nanosheets using photoinduced free radical generation and their catalytic properties,Nanoscale,2018, 10(39): 18805-18811.
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